Scientists Reverse Alzheimer's in Mice: A Paradigm Shift in Treatment (1/26/26)
Groundbreaking research challenges the long-held belief that Alzheimer's damage is permanent—and offers new hope for recovery.
For more than a century, Alzheimer's disease has been considered irreversible. Once cognitive decline begins, the thinking went, we can only hope to slow the progression—never restore what was lost. This month, researchers from University Hospitals, Case Western Reserve, and the Cleveland VA Medical Center published findings that challenge this fundamental assumption.
The team discovered that the brain's failure to maintain healthy levels of a cellular energy molecule called NAD+ plays a major role in driving Alzheimer's. When they restored NAD+ balance in mice with advanced Alzheimer's, something remarkable happened: the brain repaired its damage. Cognitive function was fully restored. Even the blood-based biomarkers used in human Alzheimer's research returned to normal.
A Message of Hope
"For more than a century, Alzheimer's has been considered irreversible," said senior author Dr. Andrew Pieper. "Our experiments provide a proof of principle that some forms of dementia may not be inevitably permanent." These words carry profound weight for the millions of families caring for loved ones with Alzheimer's.
It's important to be clear: this research was conducted in mice, and mouse brains are not human brains. The researchers caution against equating their experimental approach with over-the-counter NAD+ supplements, which work differently. Carefully designed human clinical trials are needed before we know whether similar strategies could help people.
What This Means for Caregivers Now
While we await human trials, this research fundamentally changes how we might think about Alzheimer's care. If the disease is potentially reversible, then every intervention that supports brain health—including music therapy, cognitive engagement, physical exercise, and social connection—becomes even more important. We're not just making people comfortable; we may be helping preserve or protect brain function that could someday be restored.
For families in the midst of caregiving, I know how hard it is to hold onto hope. But this research tells us that the scientific community hasn't given up on finding treatments that go beyond slowing decline. The damaged brain can, under some conditions, repair itself. That possibility should inspire us all to continue the work of caring, connecting, and advocating for the people we love.
References:
1) s://www.sciencedaily.com/releases/2025/12/251224032354.htm
3) s://www.foxnews.com/health/alzheimers-disease-could-reversed-restoring-brain-balance-study-suggests
